Published By : Leafly

Why is THC intoxicating and CBD is not? How can one cannabinoid alter the mind so profoundly, and the other seemingly not at all?

When we’re talking about cannabis and euphoria, we’re dealing exclusively with CB1 receptors, which are concentrated in the brain and the central nervous system. The difference between CBD vs. THC comes down to a basic difference in how each one interacts with the cannabinoid 1 (CB1) receptor. THC binds well with CB1 cannabinoid receptors. CBD has low binding affinity for CB1 receptors. That’s where the two diverge.

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